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A new colorimetric method for determination of procaine in pharmaceutical preparations via oxidative coupling organic reaction | ||
| journal of kerbala university | ||
| Article 1, Volume 4, Issue 3, 2008, Pages 236-242 PDF (0 K) | ||
| Authors | ||
| amy. Yahya. Y. farid; Muneer A.AL-Da; Mouyed. Q. Al; ; Mohammed jassim hamzah | ||
| Abstract | ||
| A new and sensitive colorimetric method for determination of procaine in pure and pharmaceutical preparations has been developed. It is based on coupling the nucleus of procaine molecule which is p-amino benzoic acid(PABA) with promathazine HCL in the presence of sodium periodate as oxidizing agent in an acidic medium.The product stable green-bluish coloured has a λ max=610nm.The calibration curve is liner over the range of (0.4-18 µg .ml-1)of p-amino benzoic acid with a molar aborpitivity of 1.718x104 l.mole-1.cm-1,a sandal sensitivity of 0.0079µg.cm-2,a relative error of(-1.15)-2.26% and a relative standard deviation of(0.24-1.45%) depending on the concentration of p-amino benzoic acid.The proposed method is applied satisfactorily to pharmaceutical preparations containing procaine | ||
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