Human Cytomegalovirus Up-regulates Nuclear Factor-κB in Women with Spontaneous Abortion

Al-Obaidi, Baqer; Asmaa,

	Human Cytomegalovirus Up-regulates Nuclear Factor-κB in Women with Spontaneous Abortion
Journal of the Faculty of Medicine
Article 1, Volume 50, Issue 4, 2008, Pages 484-487
Authors
Baqer Al-Obaidi;
Abstract
Background: Human cytomegalovirus (HCMV) infection during pregnancy causing serious problems through induction of viral genes that enhance the expression of different cellular factors ending in failure of pregnancy. Patients and Methods: Paraffin embedded sections of curate samples were obtained from 34 women had spontaneous abortion, and 5 women had elective termination of pregnancy (as control), and then subjected for immunohistochemistry analysis to detect human cytomegalovirus (HCMV) early protein, and in situ hybridization technique to detect nuclear factor-κB (NF- κB) mRNA. Results: Only nine out of 34 women with spontaneous abortion were positive for HCMV early protein, with a significantly higher expression of NF-κB in HCMV positive cases as compared with HCMV negative and the control group (p = 0.001). Conclusion: This study strengthen the possibility that HCMV infection may play an important role in the pathology of pregnancy loss on multidirectional bases include inducing the expression of the transcriptional factor; NF-κB.
Keywords
HCMV; abortion

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