Synthesis and Antibacterial Activity of some Hdrazides, Substituted Thiosemicarbazide, 1,3,4-Oxadiazoles, Thiadiazoles and 1,2,4-Triazoles

Daoud, K.M.; Al-Obaydi, A.W.; Mohammed, M.J.

	Synthesis and Antibacterial Activity of some Hdrazides, Substituted Thiosemicarbazide, 1,3,4-Oxadiazoles, Thiadiazoles and 1,2,4-Triazoles
Iraqi National Journal Of Chemistry
Article 1, Volume 0, Issue 31, 2014, Pages 531-542
Authors
K.M. Daoud; A.W. Al-Obaydi; M.J. Mohammed
Abstract
Abstract In the present work five ethyl esters (1-5) were treated with hydrazine hydrate in ethanol to give the corresponding acid hydrazides (6-10). The hydrazides were converted to substituted thiosemicarbazides (11-14) by their reaction with phenyl isothiocyanate, while on heating at 150-200 C substituted 1,2,4-triazole was obtained (15). The thiosemicarbazides were converted to substituted 1,2,4-triazoles (16-19), 1,3,4-oxadiazoles (20-22) and 1,3,4-thiadiazoles (23-26) by their reaction with sodium hydroxide, mercuric oxide in methanol and concentrated sulfuric acid respectively. The synthesized compounds (7, 11, 15, 18, 20, 22, 24 and 26) were tested against Staph. Aureus, Bacillus subtilis, Proteus mirabilis, E. coli, K. pneumonia and Pseudomonas aeroginosa, and the compounds (10, 16, 17, 19, 23 and 25) against E. coli, Pseudomonas aeroginosa, Proteus mirabilis and Staph. aureus. The structures of the synthesized compounds were established by physical and spectral methods.

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