Clinico-Pathological Study Of Sickle Cell Anemia In Basrah

HASSAN AL-TIMIMI, ALT

	Clinico-Pathological Study Of Sickle Cell Anemia In Basrah
Medical Journal of Babylon
Article 1, Volume 1, Issue 1, 2004, Pages 18-24
Author
ALT HASSAN AL-TIMIMI
Abstract
Basrah is located in the world's map of geographical distribution of sickie cell anemia (SCA) that canies significant morbidity. Data on the hue gene ftequency, clinical spechum of the problem and hematological and biochemical profiles ofpatients that could define the natural history of the problem in our country arc scaice.ln the present study the medical files ofpatients with SCA admitted to Basrah Teaching hospitals (1990-1998) were review rcview. Data on age, sex, residence, clinical prcsentations, mean hemoglobin level, frequency of readmissions and blood translllsions were collected. The clinical presentation of SCA were found to be protean. The most Iiequenr one was acute painful crisis (40%) following by aplastic crisis (10%) and hemolyric crisis (9%). hfection comprised 30% of total presentation including u nary tact infection, osteomyelitis and gastrointedtis. Splenomegaly, hepalomegaly and hlpersplensim were teported in different ftequencies (50%, 42% and 200lo respectively). Splenic sequestration was the the least common presentation (270). The mean hemoglobin level was 7.5t 1.2 gm % and the total frequencies of re-admission and blood transfusion were 80-92 respectively. It is concluded that the clinical severity of SCA in Basrah tends gene.ally to be more sever than Mosul and Baghdad cases. Different hemoglobin haplotypes, possible interaction belween sickle cell gene and other red blood ceiis genetic marker such as tl'nlassemia and G6PD deficiency and enviroDmental factors are probable etiological for more sever clinical presentation in Basrah . Ke1'rvords: Sickle cell anemia, Clinical presentation, Basrah

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