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Cytidine Deaminase Activity In Breast Cancer | ||
| Medical Journal of Babylon | ||
| Article 1, Volume 1, Issue 1, 2004, Pages 32-39 | ||
| Authors | ||
| Oda M. Y. Al-Zamely; Mufeed J Ewadh; Abdulsamie H. Alta | ||
| Abstract | ||
| Cytidine deaminase (CTD) catalyzed the deamination of cytidine (CR) to uridine (UR) is a cytoplasmic enzyme existing in many kind of cells and widely distributed among mammalian tissues. It has beel1 reported to be a sensitive indicator in several types of abnormalities. CTD activities in sera of thirty-eight females with breast cancer (BC) and twenty-five healthy females as a contrcl were measued using a spectrophotometric method. Also electophoretic patte.n ofsera of patients with BC and healthy fernales were assayed using polyacrylamide gel electrophoresis (PAGE) to differentiate between normal and abnomal proteins existing in the two cases. Compared with healthy females, CDA activities found to significantly increase in sera of patients with BC (4.96+ 2.34, 13.3 + 3.72 U/L) (P < 0.000) respectively. PAGE profile of sera of patients with BC shows wide variety than that of nomal females. These results may consider a novel biochemical marker to aid in the diagnosis of BC. | ||
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