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Significance of Agnor Statuus in Epithelial Salivary Gland Tumors | ||
| Medical Journal of Babylon | ||
| Article 1, Volume 2, Issue 4, 2005, Pages 379-387 | ||
| Authors | ||
| Balkees T. Garib; Suha A. H.Hindi | ||
| Abstract | ||
| The present retrospective wo* was conducted on epilhelial salivary gland tumo$ (ESCTS) (benign and rnalignant ) anong lmqi patients with the main objective ofchancterizing differenl biological behavio. of different salivary gland tumors- The AgNOR status was assessed in relation to the cellular activity of This study comprised a total of40 patients diagnosed as salivary gland tunors in rhe depadmenr oforal-Pathology at college of Dentistry, Universiq, ofBaghdad.Thjs se es consisted of(18) cases of benig'r tumon and (22) cases ofrnalignant tumors thal affected both major and minof salivaD, glands. The convenlional examinalion revealed that,the 18 cases ofbenign ttrmorc consisted of la cases (i5%) pleonorphic adenoma and 4 cases ( 1 o%)caDalicular adenoma while the (22) cases of malignanl lumo|s consisted of 9 cases (22.5%) mucoepidermoid carcinona,Scases (20%) aderocystic carcinoma and scases (12.5%) adenocarcinolna. 'l'he estimatior of AgNOR status was car ed out on 4 $n tumor secrions using one step silvef staining techDique. lhe mean AgNOR count ,was calculaied and the size and distribution of AgNOIt dors werc subjectively evaluated as fine or lafge aDd grouped, peripheral or scattered respectively. Data demorstrated drar benign tumoN has less mean AgNOR count (3.61) than malignant lumors (7.is).and tlre difiercnce erseen I en, s q,lr .r.ally .rgnifica.,l Results showed tlat there is significant difTefeDc< beL$ccn pleomoryhi( rderonD ir(l iirll LUlaf adenonra. Malignant iumors sholved significanl differeDce among differ€nt types and irterestingly ther€ js a significanl diffcrcnce beLwcen two dillbrent gfolr,th pattem ofadenocyslic carcinonra (solid and cribritom Evaluarion ofrhe size and distribLdon ofAgNOR dots within these tumors revealcd ihar benign rumors presented mainly whh large NORs dots (52-59%),aggrcgated in grouping paftern mainly (67-71%) ,while malignant tLrmoN presenied mainly with fine size NoRs(63-68%),distributed in grouping paftern for adenocyslic carcinoma (61%) and mucoepidermoid carcinoma (50%) which is more asgressive . In conclusion our resuirs indicated that AgNOR status is an additio al useful tool in diffefentiation betweeD bengnr and nraligDant ESGTS, and prcdicting lhe degee of aggressiveness of each tLnnof which may a1facl the pfognosis oflhesc lumors. Fof the best ofour knowledge this is the first study on ESGTS diagnosis, usnrg AgNOR marl(er as indicator for aggressiveness and prognosis ofthese tumor | ||
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