- All Journals
- Al-Qadisiyah University
- Basrah University
- Kirkuk University
- Mosul University
- The Iraqi Borad for Medical Specialization
- University of Anbar
- University of Technology
- Al Mustafa University
- Al-Zahraa University for Women
- Alnoor University
- Kunooz University
- Misan University
- Ninevah University
- Tikrit University
- University of Al-Hamdaniya
- University of Kerbala
Cigarette Smoking and Lung Destruction Pathology: Nicotine Induces Leukocytes Chemotaxi | ||
| Medical Journal of Babylon | ||
| Article 1, Volume 2, Issue 4, 2005, Pages 388-396 | ||
| Authors | ||
| Fadhil Frhood M Algbori; Ali Hassan Al-Timimi | ||
| Abstract | ||
| lnflamnatory cells accunrulate within lhe lungs of cigareite smokeN. Cun€nt concepls suggesl lhar drese cells can induce pfotease-antiproiease aDd/o. oxidant antioxidaDt inrbalance(s). which may damage the nor al lung alveolar and inlerslitial structurcs. Because type 1l pneumocylcs line the alveolaf sDace, and because lhe inflammatory cells migrale and rcside at the alveolus, we believcd thal the type II pneumocytes nighl felease chenrotaclic aciivity for neutrophils and monocytes in responsc. To test thh hypolhesis, type II pneumocytes cells dissected 60 rat lung were exposed to smoke exlract and the supe.natant fluids were evaluated for the neutrophil and monocyte chemotaciic activity (NCA and MCA) by a blnrd'well chamber technique. The results demonshate that the alveolaf epithelial like cell. rcleased NCA and MCA in response to smoke extract in a dose- and time'dependent marner (P < 0.05). Checkefboad analysis showed that the activity was chemotaclic. Lipoxygenase inhibiro$ and cyclohexinride nnribited the release of NCA and MCA. Molecul sieve colunn chromatog|aphy showcd muhiDle peaks tor both NCA and MCA. lt is concluded that The cigarelte smoke can inactivate aDtiprotease protection, thus cigaretie srnoke may lnfluence both rnatrix damage and repair processes, ieading to hng destruction by inflamnratory pfocesse | ||
|
Statistics Article View: 64 PDF Download: 45 |
||