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Effects of Phenobarbital Monotherapy on Thyroid Function Tests in Epileptic Children | ||
| Medical Journal of Babylon | ||
| Article 1, Volume 3, Issue 1, 2006, Pages 47-50 | ||
| Authors | ||
| Imad A. Thanoon; Ashraf H. Ahmed; Shamil H. Othman | ||
| Abstract | ||
| To determine the effects of Phenobarbital (PBT) monotherapy on thyroid function tests including total T 4, total T 3 and TSH in epileptic children whose age ranged between 7-15 years. The study was conducted in the department of pharmacology, college of medicine, university of Mosul, during a period of 9 months commencing from January-2005. The patients’ group consist of 19 patients on PBT monotherapy together with a control group. Serum total T 4 , total T 3 and TSH concentrations in epileptic children on PBT monotherapy were compared with those in control group by using unpaired “t” test. We found a statistically significant reduction in total T4 levels in patients receiving PBT compared with the control group, while Total T 3 and TSH levels were indifferent statistically. All patients were in euthyroid state, there were no clinical findings of hypothyroidism. These data suggest that PBT monotherapy decreases serum total T 4 levels significantly(P<0.001), while total T 3 and TSH levels remained unaffected | ||
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