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Synthesis Of New Oxazole -4-One Derivatives From Phenyl Alanine | ||
| journal of kerbala university | ||
| Article 1, Volume 4, Issue 4, 2008, Pages 329-341 PDF (0 K) | ||
| Author | ||
| Shirin R. Rasul | ||
| Abstract | ||
| The present research includes the synthesis of fifteen new derivatives for the compound (1,3-oxazol-5-(4H)-one (1) ) which perfect the synthesis for reaction Phenyl alanine with acetic anhydride to afford 1,3-oxazol-5-(4H)-one, which complete conversion to 3-Amino-5-benzyl-2-methyl-3,5-dihydro-4H-imidazol-4-one (2) to react with the hydrazine hydrate %99 ethanol boiling ,take on the component (2) for primary material was used because it contains the material of NH2 active in the synthesis of several Schiffs bases (3 - 6),in order to heat them with different aromatic aldehydes or keton in the solvent ethanol. Later on several of Schiffs Bases to were used prepare a new derivatives(7 - 10) by added ( benzoyl chloride) to (isomethine) (-CH=N-) group at the last compounds (11 - 14) by substituting (Cl) group in the (7 - 10) compound to group (S-C=NH NH2) from its reaction with thiourea in the presence of (Na2CO3),on the other hand when the essential compound (2) is heated with bromo acetic acid in the basic midem for period of (7hours) that lead to forming the new derivatives (15) The synthesized compounds were confirmed by using some spectroscopy methods (FT-IR, UV.-Visible,C.H.N) | ||
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