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Detection of CagA in H. Pylori Gastric Illness Using in Situ Hybridization | ||
| Diyala Journal For Pure Science | ||
| Article 1, Volume 6, Issue 3, 2010, Pages 85-90 | ||
| Authors | ||
| Nidhal A. Mohammed; Ahmed S. Abood | ||
| Abstract | ||
| Background: H. pylori had been recognized as the causative agent of several gastric diseases and possessed wide variety of virulence factors, one of most important factors is CagA. Objective: This study investigated the expression of CagA cytotoxin on the gastric epithelial cells in patients with Helicobacter pylori gastric illness by using In Situ Hybridization technique. Methods: Paraffin embedded tissue had been made form biopsies taken from 30 patients undergo O.G.D. and selected according to exclusion criteria. In addition 10 apparently healthy volunteers were included as a control group. Results: The CagA cytotoxin was detected in 21(70.0%) patients out of 30 and 9 (30.0%) gave negative results, on other hand control group showed no positive results. Conclusions: The CagA positive H. pylori strains cause the majority of H. pylori related gastric illness. | ||
| Keywords | ||
| Helicobacter Pylori; Gastritis; CagA; In situ hybridization | ||
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