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Synthesis and biological activity of monocyclic Spiro Azetidine-2- one. | ||
| Journal of College of Education for Pure Science | ||
| Article 1, Volume 2, Issue 1, 2012, Pages 67-74 | ||
| Authors | ||
| Sanaa Mahdi Auribi; Athraa Hameed Mekky; Zainab Abed Ali Mohammad | ||
| Abstract | ||
| The present work include the synthesis of 3-(4-chlorophenyl)-2-[4-(diethylamino)phenyl]-5,8-dithia-2- [3.4]octan-1-one as potent bactericidal agents are described. The compound prepared by r 4eacting 1,3—dithiane-2-carbonyl chloride with N-(4–diethylamino) phenyl -4-chloro benzylidin in the presence of triethylamine in dry dichloromethane at room temperature characterized by IR , H-NMR and Mass spectral . This compound was screened for this antibacterial activity against S. aureus, E. coli, B. subtilis and P.aeruginosa. This compound carrying 3- (4-chlorophenyl)-2- [4-(diethyl amino) phenyl]-5,8-dithia-2- aspiro[3.4]octan-1-one moiety showed significant biological | ||
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