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Measuring MDA & GSH as Biomarkers for Oxidative Stress in Bladder Cancer Patients | ||
| journal of kerbala university | ||
| Article 1, Volume 5, Issue 1, 2009, Pages 127-131 PDF (0 K) | ||
| Author | ||
| Dafer A. Faysel Al-Kufy | ||
| Abstract | ||
| The aim of this study was to evaluate the oxidative stress in bladder cancer. Thirty bladder cancer patients of ages 66.4±14.2 years and, 33 healthy individuals of ages 61±3.8 years used as a control group were enrolled. The concentrations of malondialdehyde (MDA), reduced glutathione (GSH) were measured in sera of patients and the control group. The results analyzed by ANOVA analysis don’t exhibit a significant elevation for MDA concentration, while seen a significant (P<0.005) decrease for GSH concentration were indicated in the group of patients when compared with those of the control group. Smoking was found to increase significantly (P<0.005) the levels of MDA and decrease significantly (P<0.005) the levels of GSH in the group of patients when compared with healthy individuals. MDA levels were illustrated to increase significantly (P<0.001) in patients of current smoking and significant (P<0.005) decrease for GSH levels when compared with control group. | ||
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