Effect of garlic-apple vinegar mixture on hyper-cholesterimia induced rabbits

J.Al-Bayati, Nisreen

	Effect of garlic-apple vinegar mixture on hyper-cholesterimia induced rabbits
KUFA MEDICAL JOURNAL
Article 1, Volume 15, Issue 1, 2012, Pages 57-66
Author
Nisreen J.Al-Bayati
Abstract
Garlic contains hypolipidemic and antioxidant compounds acts on prevention of cardiovascular and other metabolic diseases, such as atherosclerosis high-lipidemia, thrombosis hypertension and diabetes .This study have investigated the efficacy of garlic-apple vinegar mixture intake for prevention of dys-lipidaemia which considered as the major cause of arterial dysfunction. Study the effects of low dose of mixture for a period of sixty days, and attempt to bridge the gap between studies on apple vinegar alone and garlic studies to get benefits of their combination. The study carried on male rabbits received hyper-cholesterolemic diet (1%cholesterol) with treatment (mixture group) for 8 weeks which compared with control and hyper-cholesterolemic groups reveal significant decrease in total cholesterol(TC)low density lipoproteins(LDL)and triglyceride (TG) with significant increase in high density lipoproteins(HDL).Moreover the histological changes sustenance these results. Conclusion: the mixture of garlic apple-vinegar have a clear role in reducing the level of lipids in the serum and thus reduce the risk of atherosclerosis, as the low dose therapy of the mixture gave an excellent results with low side effects of both components. The present study prove okay results after obtaining their synergistic benefits as a mixture compared to the results discovered by histological examinations of abdominal aorta in the hyper-cholesterolemic group on one hand and the treated group with mixture on the other hand.

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