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The Role of Addition of Diclofenac Sodium to Imipramine in Treating Children with Nocturnal Enuresis | ||
| Iraqi Postgraduate Medical Journal | ||
| Article 1, Volume 9, Issue 1, 2010, Pages 16-20 PDF (0 K) | ||
| Author | ||
| Samir Ali Muter | ||
| Abstract | ||
| ABSTRACT: BACKGROUND: Nocturnal enuresis presents a common medical problem all over the world, over many years various therapeutic options have been tried; none was proved to be superior, because the defect occurs at many levels in the urinary tract and its neuronal control. Nowadays prostaglandins have been proved to play a role at renal, bladder, urethral and sympathetic control of urinary system. OBJECTIVE: We evaluated the role of diclofenac sodium when added to the conventional imipramine therapy in treating patients with primary nocturnal enuresis. PATIENTS AND METHOD: 70 children complaining of nocturnal enuresis were enrolled in this study, half of them were given imipramine alone and the other half were given a combination of imipramine and diclofenac sodium at night before retiring to bed, and the number of wet nights per week was recorded on a calendar sheet by the parents over 4 weeks, those who showed more than 50% reduction in the number of wet nights a week were regarded as responders, who were followed after cessation of treatment over another 6 weeks to look for relapse. RESULTS: Of the patients treated with imipramine alone 57.14% (20/35) showed more than 50% decrease in the number of wet nights weekly compared to those treated by imipramine and diclofenac sodium who showed 84.84% (28/33) response rate (> 2.5 SE of difference between responding proportions). The relapse rate after stopping treatment was 60% (12/20) in the first group compared to 32.1% (9/28) which exactly two times the SE of difference between relapsing proportions. CONCLUSION: The addition of diclofenac sodium to imipramine in treating patients with primary nocturnal enuresis might have caused a highly significant higher response rate and a fairly significant lower relapse rate after cessation of treatment. | ||
| Keywords | ||
| imipramine; Diclofenac sodium; nocturnal enuresis | ||
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