A study of effect of carvedilol on serum creatine kinase- MB  and troponin I levels in doxorubicin treated females with breast cancer

Hassan Abboud Al-Rekabi, Sameer; D.M,

	A study of effect of carvedilol on serum creatine kinase- MB and troponin I levels in doxorubicin treated females with breast cancer
KUFA MEDICAL JOURNAL
Article 1, Volume 15, Issue 1, 2012, Pages 314-319
Authors
Sameer Hassan Abboud Al-Rekabi;
Abstract
Background: Doxorubicin based regimen is the most common treatment of breast cancer which is highly complicated by cardiotoxicity. Aim: To clarify the possible effects of carvedilol on serum CK-MB and Troponin I in doxorubicin based regimen in females with breast cancer. Patients and Methods: A total of 16 females with breast cancer were included in this study. The patients were randomized into 2 groups , 8 patients each. Group I included patients were treated with doxorubicin based regimen for 6 cycles with 21 day apart. Group II included patients were received doxorubicin based regimen with carvedilol 3.125 mg , orally , twice daily for 5 days , for 6 cycles. Serum CK-MB and Troponin I were measured at zero time and 3 days after 2nd, 4th and 6th cycles in both groups. Results: The following results were obtained: 1- Treatment with doxorubicin based regimen caused highly significant elevation in serum CK-MB and Troponin levels after 2nd, 4th and 6th cycles in comparison to baseline readings (P < 0.01). 2- Combined CAF + Carvedilol 3.125 mg orally twice daily for 5 days caused highly significant decrement in serum CK-MB and Troponin I levels compared with that of doxorubicin based regimen group (P < 0.01). Conclusion: From the present study , we can conclude that Carvedilol causes highly significant decrease in serum CK-MB and Troponin I levels in doxorubicin treated patients.
Keywords
Carvedilol; Doxorubicin; Cardiotoxicity; Troponin I

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