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Cardiovascular Manifestations of Primary Hypothyroidism | ||
| Iraqi Postgraduate Medical Journal | ||
| Article 1, Volume 9, Issue 2, 2010, Pages 113-119 PDF (0 K) | ||
| Authors | ||
| Ahmed Shaker Al-Zaidi; Adil S .Abdul-Ghafour; Abdulla J Minshed Al-Farttoosi | ||
| Abstract | ||
| ABSTRACT: BACKGROUND: Primary hypothyroidism accounts for 90 to 95 %of all cases of hypothyroidism. Thyroid hormone deficiency increases systemic vascular resistance, decreases contractility and slow the heart rate . OBJECTIVE: To investigate cardiac changes in primary hypothyroidism. METHODS: In this prospective study 36 patients with untreated primary hypothyroidism were compared with 30 healthy persons. Cardiovascular evaluation of all subjects had been made both clinically and by the following studies :Chest X-Ray, electrocardiography, serum lipid and Echocardiography. RESULTS:: The main cardiac manifestations of hypothyroidism were: Easy fatigability( 88.9 %(, exertional dyspnea )75%o),obesity or gaining weight( 66.7 %(, sinus bradycardia ) 47.2 %(and peripheral edema(11.1 %(Electrocardiography showed sinus bradycardia in( 47%( low QRS voltage in )33.3%( , flat or inverted T wave(27.8%), prolonged QT interval )19.5%), first degree heart block in( 19.5 %( .Echocardiography showed the following :a decrease in global systolic function, asymmetric sepal hypertrophy in )91.6%) Pericardial effusion in )38.8%).Low QRS voltage was found to be related to thyroxin level and age of the patient .No correlation was found between heart rate and thyroxin level. CONCLUSION: Primary hypothyroidism accompanied by significant changes in cardiovascular system which may explain the development of premature coronary artery disease in these patients. | ||
| Keywords | ||
| primary hypothyroidism; cardiovascular manifestations | ||
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