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Is Chlamydia Pneumonia An Independent Risk Factor In Ischemic Heart Disease | ||
| Iraqi Postgraduate Medical Journal | ||
| Article 1, Volume 9, Issue 2, 2010, Pages 151-154 PDF (0 K) | ||
| Authors | ||
| Eman Sh. AL-Obeidy; Eman Sh. AL-Obeidy | ||
| Abstract | ||
| ABSTRACT: BACKGROUND: Immune system may interplay between Chlamydia pneumoniae infection and ischemic heart disease (IHD).Major histocompatibility genes regulate innate and adaptive immunity.. OBJECTIVE: This study was established to shed light on the possible association between ischemic heart disease (IHD) with Chlamydia pneumoniae infection and HLA antigens. PATIENTS AND METHODS: Microlymphocytotoxicity assay has been applied for HLA-typing of 150 blood samples of 100 IHD patients and 50 healthy normal controls, In addition enzyme linked immunosorbant assay (ELISA) used to detedct C pnuminiae IgA and IgG. RESULTS: An increased frequency of HLA-A*2, B*35 alleland HLA-A*2-B*35 haplotype was observed for patients group versus control group with P-value (0.0001, 0.05, and 0.001) respectively. CONCLUSION: This finding demonstrated that the HLA-B*35 positive haplotypes confer the C.pneumoniae-related risk for IHD. HLA-DR3,DR4 and DR7 might play a role in AIH susceptibility | ||
| Keywords | ||
| ischemic heart disease; HLA; pneumoniae | ||
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