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Effects of glibenclamide and metformin on serum uric acid level in patients with type II diabetes mellitus | ||
| Iraqi Journal of Pharmacy | ||
| Article 1, Volume 11, Issue 1, 2011, Pages 69-74 PDF (0 K) | ||
| DOI: 10.33899/iphr.2011.49595 | ||
| Author | ||
| Najlaa Saadi Ismail | ||
| Abstract | ||
| Objectives: To assess the effect of glibenclamide and metformin on serum uric acid level in patients with type ٢ diabetes. Study design: Case control study. Subjects and Methods: This study was conducted from March ٢٠٠٩ to January ٢٠١٠. Fasting blood sugar and serum uric acid level were measured in patients suffering from type- ٢ diabetes mellitus who were referred to Al-Wafa Diabetic Center in Mosul City. Group ١: ٣٢ patients on glibenclamide therapy, group ٢: ٤٢ patients on metformin therapy and group ٣: ٤٢ patients on combination therapy, group ٤: ٣٢ patients on restricted diet, and ٢٣ apparently healthy volunteers, were taken as a control group. Results: The study showed a significant increase in the serum uric acid level of the diabetic patients as compared with the control. Glibenclamide and/or metformin showed no significant difference in the serum uric acid level in patients with type ٢ diabetes mellitus. Conclusion: Glibenclamide and/or metformin had no significant effect on serum uric acid level in patients with type ٢ diabetes mellitus. | ||
| Keywords | ||
| Uric acid; Hyperuricemia; Type; Glibenclamide; metformin | ||
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