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The effect of antioxidant supplementation in the treatment of epilepsy | ||
| Iraqi Journal of Pharmacy | ||
| Article 1, Volume 11, Issue 2, 2011, Pages 27-33 PDF (0 K) | ||
| DOI: 10.33899/iphr.2011.49893 | ||
| Author | ||
| Nazar A.K. hamid | ||
| Abstract | ||
| Aim: To assess serum level of malondialdehyde (MDA) and total antioxidant status (TAS) as a representative of oxidative stress in patients with generalized epilepsy and to evaluate the therapeutic effect of the antioxidant (vitamin E and vitamin C) on the levels of MDA,TAS and frequency of seizures attacks after two months therapy. for a period of two months as a supplementation therapy. Subjects and Methods: The study was conducted in Iben-seena Hospital in Mosul city-Iraq. Fifty three patients with generalized epilepsy were included in this study (32 male and 21 female). The study included 40 apparently healthy subjects, age and sex matched as a control group. Initially from both the patients and controls, blood samples were taken. Another blood samples were taken from the patients 2 months after vitamin E and vitamin C treatment, blood samples were analysed for serum MDA and serum TAS. Result: Serum MDA was found to be significantly higher ( P<0.001) and serum TSA was significantly lower (P<0.001) in patients with generalized epilepsy prior vitamin E and vitamin C supplementation in comparison to controls. After vitamin E and C supplementation there was a significant reduction (P<0.001) in the serum MDA levels with a significant increase (P<0.001) in the serum TAS. Also we found a reduction in seizure frequency of greater than 70% after vitamin E and C supplementation. Conclusion: a significant reduction of TSA was reported in patients with epilepsy. Administration of vitamin E and C produced a significant reduction of serum MAD levels and a significant elevation of serum TAS, associated with a reduction of greater than 70% of seizure frequency. The study suggests the administration of vitamin E and C as adjunct to antiepileptic drugs. | ||
| Keywords | ||
| epilepsy; oxidant; vitamin E; vitamin C | ||
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