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The relation of plasma level of atrial and brain natriuretic peptide to left ventricular function in subjects with congenital heart disease | ||
| KUFA MEDICAL JOURNAL | ||
| Article 1, Volume 14, Issue 1, 2011, Pages 1-9 | ||
| Authors | ||
| Dr.Yesar M.H. Al-Shamma; Dr.Riyad Waheed; Dr. Abdul - Aziz Ahmed Aziz | ||
| Abstract | ||
| Aim: To assess Atrial and Brain natriuretic peptide levels in subjects with congenital heart disease, and their role in evaluation left ventricular function among these subjects. Methods: Sixty two subjects with congenital heart disease (28 males, 34 females) aged1-20years, were studied in the Echocardiography unit at Ibn-Sena teaching hospital in Mosul, during the period of 1 year, from 1st October 2004 to 30th September 2005. The study also included 20 apparently healthy volunteers (9 males and 11 females) aged 2-20 years as control group. for every subject participate in the study Plasma concentration of ANP and BNP, and left ventricular ejection fraction were determined Results: The mean of plasma level of ANP and BNP were significantly higher in cyanotic subjects with congenital heart disease compared with non-cyanotic (P≤ 0.002; P≤ 0.0001) and control subjects (P≤ 0.001; P≤ 0.0001). The mean of LVEF% was significantly lower in cyanotic subjects compared with non-cyanotic subjects (P≤0.0001) and control group (P≤ 0.0001), but there was no significant difference in the mean of LVEF% between non-cyanotic subjects and control group. The result of study showed a significant negative correlation between the mean of BNP and mean of LVEF% in cyanotic subjects (r=-0.8; p≤ 0.01), non-cyanotic subjects (r=- 0.7; p≤ 0.01), groups I (r=- 0.8; p≤ 0.01), groups II(r=- 0.75; p≤ 0.01) and groups III (r=- 0.69; p≤ 0.02). There was also a significant negative correlation between the mean of ANP and mean of LVEF% in groups I (r=- 0.38; p≤ 0.02). Conclusion: the result of this study reviled that increased plasma level of ANP and BNP are common in subjects with congenital heart disease and it s strongly correlated with the ventricular function. However, the plasma level of BNP appear to be superior to ANP as efficient, non-invasive cardiac markers for facilitating diagnosis of various pattern of congenital heart disease. | ||
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