H. J. Al-Qaisi, Z., H. J. Al-Qaisi, A., H. R. Tomi, I. (2010). Synthesis, Characterization and Effect of bis-1,3,4-Oxadiazole Containing Glycine Moiety on the Activity of Some Transferase Enzymes.. , 23(3), 190-204.
Z. H. J. Al-Qaisi; A. H. J. Al-Qaisi; I. H. R. Tomi. "Synthesis, Characterization and Effect of bis-1,3,4-Oxadiazole Containing Glycine Moiety on the Activity of Some Transferase Enzymes.". , 23, 3, 2010, 190-204.
H. J. Al-Qaisi, Z., H. J. Al-Qaisi, A., H. R. Tomi, I. (2010). 'Synthesis, Characterization and Effect of bis-1,3,4-Oxadiazole Containing Glycine Moiety on the Activity of Some Transferase Enzymes.', , 23(3), pp. 190-204.
H. J. Al-Qaisi, Z., H. J. Al-Qaisi, A., H. R. Tomi, I. Synthesis, Characterization and Effect of bis-1,3,4-Oxadiazole Containing Glycine Moiety on the Activity of Some Transferase Enzymes.. , 2010; 23(3): 190-204.

Synthesis, Characterization and Effect of bis-1,3,4-Oxadiazole Containing Glycine Moiety on the Activity of Some Transferase Enzymes.

Ibn Al-Haitham Journal For Pure And Applied Science
Article 1, Volume 23, Issue 3, 2010, Pages 190-204
Authors
Z. H. J. Al-Qaisi; A. H. J. Al-Qaisi; I. H. R. Tomi
Abstract
We described herein the synthesis of novel bis-1,3,4-oxadiazole containing glycine moiety. N-{5-[5-(4-methoxyphenyl)-1,3,4-oxadiazole-2-yl-sulfanyl]-1,3,4-oxadiazole-2-yl-methyl}-4-methoxybenzamide was fully characterized by elemental analysis, FT-IR and 1H NMR spectroscopy. Also this study was designed to show the effects of bis-oxadiazole compound on the activities of some transferase enzymes such as: GOT, GPT and γ-GT in sera. This compound demonstrated activation on GOT and GPT activities, inhibitory effects on the γ-GT activity. These effects increased with the increasing of the concentration of the compound. The causes of the increases and decreases in the enzymes activities are discussed.
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