Praziquantil use in Amebic dysentery

FICMneph,; CABP,; F.F.Sharba Pediatric Nephrologists, Dr.Yasir; DCH,; MBChB,

	Praziquantil use in Amebic dysentery
KUFA MEDICAL JOURNAL
Article 1, Volume 14, Issue 1, 2011, Pages 221-224
Authors
; ; Dr.Yasir F.F.Sharba Pediatric nephrologists; ;
Abstract
Amebiosis was one of the commonest causes of diarrial illness in pediatric age group in developing countries and there where multiple drugs used in its treatment .We selecting an infected and symptomatic patients and excluding the others. Those patients treated in different manner. Also divided in different age groups. We had two groups .first group treated with usual way by mitronidazol 50mg/kg/day for 10 days adding to that diloxanide furoate 20mg/kg/day for same duration to get ride of cyst form .The second group with praziquantil which subdivided in other two groups .One with 25mg/kg /day in single dose and other with 40mg/kg/in two divided doses 6 hour apart .Those patients had been followed for the response and the side effects to the drugs. The results are comparable and statistically no significant difference between the two groups. Regarding the side effect also no significant difference between both groups. The response to treatment depending on three successive microscopically stool tests (after3 days of treatment 3days between each test and other) and on the clinical response .This manner of follow up was true for 85% only and because it was the available way now in Iraq, So we advice to repeat such search in a larger number of patients and to depend on more recent PCR method to prove response to treatment. The only significant of praziquantil use was the short duration of treatment (single dose).The most significant side effect of praziquantil use was the bad test.

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