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Antimicrobial Activity Of Lincomycin and Gentamicin delivered from Chitosan and Chitosan-Gelatin Matrices | ||
| journal of kerbala university | ||
| Article 1, Volume 4, Issue 2, 2008, Pages 171-180 PDF (0 K) | ||
| Authors | ||
| Hanaa Jaafer jabaar AL; | ||
| Abstract | ||
| The antimicrobial activity of lincomycin and gentamicin released from chitosan and chitosan-gelatin matrices against gram positive and gram negative bacteria were studied. The inhibition zone diameter were determined After (24,48) hrs of incubation using agar diffusion assay . The results showed that both matrices were very active to deliver the antibiotics.there are significant increasing p<0.05 in inhibition zone after 48 hrs compared with 24 hrs of incubation. Also there is non significant increasing in the antibiotics delivery in chitosan-gelatin matrix. This study suggest to use such matrices in drug delivery system for local (directed) bioavailability of compound antibiotic against gram positive and gram negative bacteria at the same time which is very important in the treatment of some bacterial infections. | ||
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