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Spectrophotometric Assay of Dipyrone in Pharmaceutical Preparations Via Oxidative Coupling Reaction with | ||
| Journal of Education and Science | ||
| Article 4, Volume 21, Issue 2, 2008, Pages 28-38 PDF (309.99 K) | ||
| DOI: 10.33899/edusj.2008.51237 | ||
| Authors | ||
| E.S. Salih* ; M M. Al-Sharook | ||
| Abstract | ||
| Abstract A simple, rapid and highly sensitive spectrophotometric method has been described for the determination of dipyrone in a bulk and in dosage forms. The method depends on the organic oxidative coupling reaction of dipyrone with m-toluidine in the presence of potassium hexacyanoferrate (III) in aqueous solution to form purple product measured at 530 nm. Beer’s law is obeyed in the concentration range 0.4-10.0 g.ml-1 with accuracy (average recovery) of 99.71% and precision (RSD) is less than 2%. The molar absorptivity is 40770 l.mol-1.cm-1 with LOD 0.051 g.ml-1 and LOQ 0.167 g.ml-1. The analytical results agree favourably with official method (iodimetric method) and also with certified values. | ||
| Keywords | ||
| spectrophotometric Assay; pharmaceutical preparations; oxidative coupling reaction | ||
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