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Synthesis of Some Phenolic and Amino derivatives of Cinchoninic Acid | ||
| Journal of Education and Science | ||
| Article 5, Volume 21, Issue 2, 2008, Pages 39-48 PDF (277.65 K) | ||
| DOI: 10.33899/edusj.2008.51238 | ||
| Authors | ||
| M. A. Al-Iraqi* ; K Al-Naimi; A Al- Sabawi | ||
| Abstract | ||
| ABSTRACT Treatment of cinchoninic acids (1a,b) with allyl bromide afforded compounds (2a,b), and the hydrolysis of (2a) gave the 2-(4`-allyloxyphenyl) cinchoninic acid (4) . Glycedylation of compound (1a) afforded compound (3a), while glycedylation of compound (1b) gave compounds (3b) and (3bb). The acetylation of the acids (1a,b) gave the acetyl derivatives (5a,b) . Benzylation of the amino compound (1b) with m-fluorobenzyl chloride afforded compound (6) . The reaction of compounds (1a,b) with allyl isothiocyanate or amino compound with carbon disulfide afforded thiocarbamate (7a), thiourea (7b) and dithiocarbamic acid (8) which is used as a synthone to prepare allylic ester of dithiocarbamate (9) respectively . Finally Compound (1b) can be transformed to a glycene derivative of cinchoninic acid (10). The synthesized compounds were confirmed by the physical and spectral means in addition to the functional groups systematic identification . | ||
| Keywords | ||
| Synthesis of Some Phenolic; Amino derivatives; Cinchoninic Acid | ||
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