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Spectrophotometric Determination of Mesalazine Via Arsenazo III- Cerium(III) Reaction | ||
| Journal of Education and Science | ||
| Article 2, Volume 24, Issue 1, 2011, Pages 13-21 PDF (0 K) | ||
| DOI: 10.33899/edusj.2011.51507 | ||
| Author | ||
| Zeena Z. Al-Abdaly | ||
| Abstract | ||
| Abstract A simple and sensitive spectrophotometric method has been developed for the determination of mesalazine (5-aminosalicylic acid) in pure form and in its pharmaceutical preparation(capsule). The method is based on the oxidation-reduction reaction between mesalazine and cerium (IV) ion, then reaction of cerium(III) with arsenazo III reagent in acidic medium to produce a green-blue complex, which is stable, water soluble and has a maximum absorption at 654 nm with a molar absorptivity of 2.103×105 l.mol-1.cm -1. Beerُ s law is obeyed in the concentration range of 0.5 to 14 µg of mesalazine in a final volume of 25 ml. The proposed method has been applied successfully for determination of mesalazine in pharmaceutical preparation (capsule). | ||
| Keywords | ||
| spectrophotometry; Mesalazine; Arsenazo; cerium | ||
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