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The mean AgNOR values in relation to HER-2/neu overexpression In a series of Iraqi women | ||
| KUFA MEDICAL JOURNAL | ||
| Article 1, Volume 12, Issue 2, 2009, Pages 128-136 | ||
| Author | ||
| Dr. Esraa Abdul-Aal | ||
| Abstract | ||
| Background: This study aimed to assess the usefulness of argyrophilic nucleolar organizer regions (AgNORs) in distinguishing HER-2/neu positive from HER-2/neu negative malignant breast lesions. Methods: The present investigation was performed over a period starting from September 2007 to August 2008. Formalin fixed, paraffin-embedded blocks from 90 patients with breast cancer were included in this study. A group of 25 patients with benign breast lesions (fibroadenoma) was included as a comparative group. Labeled Streptavidin-Biotin Complex (LSAB) method was employed for immunohistochemical detection of HER-2/neu. Standardized AgNORs analysis was performed on the above mentioned samples . | ||
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