Acute and Chronic Interaction Study BetweenAcetylsalicylic  Acid (Aspirin) and Captopril atDifferent Doses

Professor. Dr.Duraid A.Abbas, Assistant

	Acute and Chronic Interaction Study BetweenAcetylsalicylic Acid (Aspirin) and Captopril atDifferent Doses
KUFA MEDICAL JOURNAL
Article 1, Volume 12, Issue 1, 2009, Pages 268-276
Author
Assistant professor. Dr.Duraid A.Abbas
Abstract
The present studies were conducted to determine acute and chronic toxicity of aspirin and captopril given alone or in combination in seventy rats were used, 21 rats for acute toxicity (LD50) of aspirin, captopril and their combination in single dose, while the other forty nine rats were used to determine chronic toxicity effect which were divided into 4 groups, the control group (7 rats) received distilled water, the other three treatment groups each group (14) rats were divided into two subgroups T1&T2 according to the following oral daily dosing regiment ( aspirin subgroup 2 and 4 mg/kg , captopril, 6 and 12 mg/kg and aspirin + captopril ( 2 + 6 mg/kg and 4+12 mg/kg) respectively. LD50 was measured for all groups after their chronic treatment to determine chronic index. The results of acute toxicity (LD50) were, for captopril 4.3705 g/kg, aspirin 5.3705 g/kg and their combination (captopril 2.1295 g/kg + 2.6295 g/kg aspirin), respectively that reduced after chronic drug exposure to 3.1315 g/kg captopril, 3.1295g/kg aspirin and captopril 1.6315 g/kg + 2.1315 g/kg aspirin. Isobolographic analysis of two drug LD50 showed that there were an additive effect after acute toxic exposure and antagonism after chronic one No accumulation was reported between the two drugs and their combination after 3 month daily treatment according to the results of chronic index of all treated groups. This study indicate that LD50 isobolographic analysis for captopril and aspirin showed an additive effect after acute exposure and antagonism after chronic administration and no accumulation effect for both drugs

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