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Incidence of Erythrocyte Glucose - 6 - Phosphate Dehydrogenase Deficiency in Male Neonatal Hyper - bilirubinemia in Kerbala Region : Iraq | ||
| KUFA MEDICAL JOURNAL | ||
| Article 1, Volume 13, Issue 1, 2010, Pages 38-49 | ||
| Author | ||
| Fadhil J. Al-Toumaa and William M. Frankoolb | ||
| Abstract | ||
| Newborn G6PD deficiency screening has been recognized as an essential component of public health care in most developed and some Mediterranean countries. However, such screening is yet to be widely embraced in Kerbala region of Iraq. The aim of the present study was to determine the normal values of G6PD and the percentage of incidence of this enzyme in male neonatal jaundice of Kerbala region. A total of 318 male neonates with normal and hyperbilirubinemic patients with abnormal TSB levels were included in the study. G6PD activity was firstly detected by fluorescent spot test , then its activity levels was quantitatively measured for those patients with G6PD-deficient. Normal mean values of G6PD activity in normal healthy male neonates were 10.4 ± 1.78 IU/g Hb and for moderate G6PD-deficient neonates with total serum bilirubin , TSB < 15 mg/dl were 3.39 ± 1.43 IU/g Hb, whereas the mean activity levels in severe G6PD-deficient neonates with TSB ≥ 15 mg/dl were decreased to 0.56 ± 0.32 IU/g Hb. The frequencies identified in severe and moderate G6PD-deficient male neonatal hyperbilirubinemic patients in this region of Iraq were 9.14% and 10.77% respectively. The percentage of incidence in moderate neonatal hyperbilirubinemia (TSB < 15 mg/dl) was observed in 20.44% and that found in severe hyperbilirubinemia (TSB ≥ 15 mg/dl) was 61.95% of the total full-term neonatal cases studied. The conjugated serum bilirubin, CSB levels was decreased in both moderate and severe neonatal hyperbilirubinemic patients as compared with normal neonates. | ||
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