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The relevance of serum complement C3 with fasting blood glucose levels in obese type 2 diabetics | ||
| KUFA MEDICAL JOURNAL | ||
| Article 1, Volume 13, Issue 2, 2010, Pages 18-29 | ||
| Author | ||
| Sura Muhsin Abood | ||
| Abstract | ||
| Abstract The aim of the present study was to verify the relevance of complement, C3 & C4 with fasting blood glucose level (FBGL) in type 2 obese diabetics. To achieve this aim, 22 obese diabetic patients (12 females & 10 males) with ages of 45.23±13.83 and body mass index (BMI) of 34.52±2.15 Kg.m‾² were enrolled. To compare the results, 20 healthy individuals (10 females & 10 males) of ages 36.55± 5.36 were also included. Serum C3 and C4 levels were measured in the patients & the control group by a single immune-diffusion method. Fasting blood glucose level was estimated by the glucose-oxidase method. In the diabetic patients, serum C3 level was found to be significantly (P<0.01) elevated when compared with those of healthy individuals whereas C4 didn't show such variation. The linear regression analysis exhibited a significant positive correlation for C3 (r= 0.45, P< 0.05) with FBGL in diabetics but not in healthy subjects. Such correlation was also significant (r=0.60, P< 0.001) with the BMI values. In conclusion, C3 was found to direct the levels of FBGL in type 2 obese diabetic patients. | ||
| Keywords | ||
| FBGL; BMI; diabetes mellitus | ||
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