Comparative study between oral azithromycin and  erythromycin in male patients with severe papulopustular acne.

M.B.Ch.B,; Nory Gany, Sarmad; Pharmacology, MSc.

	Comparative study between oral azithromycin and erythromycin in male patients with severe papulopustular acne.
KUFA MEDICAL JOURNAL
Article 1, Volume 13, Issue 2, 2010, Pages 39-44
Authors
; Sarmad Nory Gany; MSc. Pharmacology
Abstract
Abstract Back ground: Acne vulgaris is a common disorders affecting79-95% of the adolescent population . Azithromycin is one of systemic antibiotic that has been recently prescribed for treatment of acne. This nitrogen- containing macrolide is a methyl derivative of erythromycin. Aim of work: To compare between the effect of oral azithromycin and erythromycin in male patients with severe papulo pustular acne treated with topical benzoyl peroxide and erythromycin drugs. Patients and methods: Fourty male patients were divided into two equal groups, the first were given oral azithromycin and the second were given erythromycin , both groups were treated with a topical erythromycin and benzoyl peroxide gel .The patients responses evaluated in each visit at the end of 4, 8 and 12 weeks of treatment . Results: Although there was more reduction in the mean acne global score showed in the group 1 when compared with the group 2 , this difference was not a statistically significant, P>0.05. This study also showed that 85% of patients who completed the treatment had a positive response in a group 1 in a comparison to 75% in a group 2. Conclusion: There was a better clinical improvement in patients treated with azithromycin , but not to a statistically significant level.
Keywords
Azithromycin; papulopustular; acne and erythromycin

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