The association of anticardiolipin antibody IgM with first trimester recurrent abortions

Mohammad Shnain Ali, Dr.

	The association of anticardiolipin antibody IgM with first trimester recurrent abortions
KUFA MEDICAL JOURNAL
Article 1, Volume 13, Issue 2, 2010, Pages 157-161
Author
Dr. Mohammad Shnain Ali
Abstract
Abstract Background: Anticardiolipin antibody has a clearly documented association with recurrent abortions in patients with autoimmune diseases; however, the association of Anticardiolipin antibody with first trimester abortions is not clearly documented in patients with no evident autoimmune diseases. Aim: To estimate the prevalence of Anticardiolipin antibody IgM in patients with first trimester recurrent abortions and to find if there is any association between them. Materials and methods: A total number of 90 women were included, 45 had history of recurrent abortions(more than 2 abortions) and 45 were healthy control women with one or more than one delivery and no history of abortions. Blood samples from the 90 women were taken for investigations including blood group, blood sugar, blood urea, complete blood picture, ESR, general urine examination, TORCH test, VDRL test and Anticardiolipin antibody IgM by ELISA technique in which levels higher than 15 MCL unit are considered to be positive, while levels below 15 MCL unit are considered to be negative. Results: Out of 45 patients, 24.4%(n=11) had history of explained recurrent abortions, 9 of them due to toxoplasmosis and 2 of them were due to cytomegaloviral infection. while 75.6%(n=34) had no explained causes. Significantly raised levels of anticardiolipin antibody IgM was present in 11 out of 45 patients i.e 24.4% of patients while IgM levels were normal in 34 out of 45 patients i.e 75.6%. The total number of explained recurrent abortions was 11 (8 out of 11 had significantly high IgM antibody i.e 72.7% while 3 out of 11 had normal IgM levels i.e 27.3%). The total number of unexplained recurrent abortions was 34 ( 3 out of 34 had significantly high anticardiolipin antibody IgM i.e 8.8% while 31 out of 34 patients had normal levels i.e 91.2%) while the antibody was negative (normal) in the control group. Patients with significantly high levels of anticardiolipin antibody who had history of explained recurrent abortions are eight. Seven of them i.e 87.5% had positive antitoxoplasma antibody IgM and one of them i.e 12.5% had positive anticytomegalovirus antibody IgM. Conclusion: Anticardiolipin antibody IgM is not associated with first trimester recurrent abortions.
Keywords
anticardiolipin antibody; recurrent abortions; first trimester

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