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Biochemical changes in patients suffering from hyperthyroidism | ||
| KUFA MEDICAL JOURNAL | ||
| Article 1, Volume 13, Issue 2, 2010, Pages 177-189 | ||
| Authors | ||
| Dakhel G.O. AL-Watify; Muhammad O.K. AL- Muhammadi | ||
| Abstract | ||
| Abstract The present study was designed to investigate changes occurring in some hormonal and biochemical changes in subjects suffering from hyperthyroidism. A total number used was 170 patients and healthy subjects of both sexes, males and females. The total number of patients was 130; 100 females and 30 males, while the number of control subjects was 40. The ages of all subjects ranged between 20 years to 55 years. It was found that hyperthyroid subjects have a significant increase (P<0.01 )of triiodthyronine (T3)and tetraiodothyronine (T4) levels and a significant decrease (P<0.01) of thyroid stimulating hormone (TSH) levels when compared with those of control groups. Biochemical changes in serum, showed a significant decrease (P<0.01) in the levels of serum reduced glutathione (GSH) in hyperthyroid patients in comparison with healthy subjects. Levels of serum alkaline phosphates (ALP) showed a significant increase(P<0.01) in hyperthyroid subjects when compared with those control subjects. Levels of calcium in both serum and urine samples showed significant increase(P<0. 01)in hyperthyroid subjects. Values of phosphorus in serum and urine samples showed significant increase(P<0. 05 ) of hyperthyroid subjects when compared with those healthy subjects. Finally, trace elements results (serum copper and zinc) showed significant decrease(P<0.01) of copper levels and a significant increase (P<0.05) of zinc levels in hyperthyroid subjects when compared with those healthy control subjects. In view of the changes summarized, the increase or decrease in some biochemical parameters may be attributed to hyper metabolic state which arise due to higher production of thyroid hormones which, in turn, affect most of body tissues. | ||
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