Histopathological effects of exogenous melatonin on connective tissues of thymus gland in male rats

Sh. Ahmed, Basim

	Histopathological effects of exogenous melatonin on connective tissues of thymus gland in male rats
Mustansiriya Medical Journal
Article 1, Volume 11, Issue 1, 2012, Pages 69-74
Author
Basim Sh. Ahmed
Abstract
Background: The neurohormone namely melatonin is secreted by the pineal body in brain. It could reach all the bodily tissues and cells; affecting their function, depending on its biological level. Thymus gland is well known to be the main central immunity director, and its wellness is rather proportional to melatonin level. Aims: This work was done to study the histopathological effect of exogenous melatonin on thymic connective tissue bulk. Materials and Methods: Dietary melatonin was supplied to adult rats, for successive 30 days. Rats were divided 6 groups. Group 1 was the control, group I was the control. Group II, III, IV, V and VI were supplied with a daily measured quantity of melatonin as 125, 250, 500, and 1000 µm/kg body wt, respectively. After the last day of treatment all animals were killed then the left thymic lobe was removed under anesthesia for histopathological study. Results: No noteworthy effect of melatonin was seen on the thymic connective tissue on its normal doses, whilst it had significant effect on the connective tissue bulk with its large doses. Conclusions: The treatment of dietary melatonin had no important effects on the rat thymic connected tissues, on its little doses, but it has considerable effects when administrated in large doses.
Keywords
Connective tissue; Melatonin; and thymus

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