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The Effect of Captopril and Ketotifin on Nasal Mucociliary Clearance in Healthy Volunteers | ||
| Mustansiriya Medical Journal | ||
| Article 1, Volume 6, Issue 1, 2006, Pages 1-6 | ||
| Authors | ||
| WALEED AL-MASHHADANI; WAFFAA N SAIEED; ABBAS AL-MUSAWY | ||
| Abstract | ||
| Nasal mucociliary clearance (NMCC) is one of the most important host defense mechanisms of the airway system, which largely depends on the coordinated ciliary beats that transfers the mucus and particles to the oropharynx. Environmental factors as well as infections, allergy and cancer may affect NMCC, a variety of inflammatory mediators and pharmaceuticals also have different effects on NMMC. It is possible to measure NMCC by the saccharine test as a simple quantitative reliable method, which can be used to measure the effects of different substances on this important function. The Aim of this double-blind, placebo controlled, randomized balanced study, is to examine the effects of captopril and ketotifin in single oral doses on NMMC in healthy human volunteers. The settings are the laboratories of the pharmacology department at the college of medicine, Al-Mustansiriya University. Group A (8 subjects) of volunteers were given single oral doses of captopril 12.5mg, while group B (8 subjects) were given single oral doses of ketotifin 1 mg, and group C (7 subjects) were given placebo. The age range for the subjects was between 19 and 20years, six females and seventeen males. Saccharin transient time (STT) in minutes, was measured by the saccharine test before the drug intake (day 1), and three hours after drug intake (day 2) at the same time of the day and under the same conditions. The study showed reduction in the STT after captopril, and increase in the STT after ketotifin, but these changes did not reach statistical significance in comparison with placebo. This study could be regarded as a base for further future studies, with the use of more frequent doses of captopril and ketotifin to discover their true effects on NMCC, and the relationship of these properties on the side effects of captopril (particularly cough), and the therapeutic effect of ketotifin. | ||
| Keywords | ||
| captopril; ketotifin; nasal mucociliary clearance | ||
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