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Biochemical Study on the Effect of Toxoplasma Infection on Liver and Kidney Function in Abino Mice | ||
| Al-Ma'mon College Journal | ||
| Article 1, Volume 0, Issue 18, 2018, Pages 120-127 | ||
| Author | ||
| Amany M. Al- Kaissy | ||
| Abstract | ||
| The present experiment was carried out to study the effect of acute toxoplasmosis on liver and kidney functions of albino mice and the effect of azithromycin on treating the infection and restoring the normal level values of liver and kidney functions to their normal values. Forty albino mice were used in this work. Liver functions were evaluated by the estimation of serum total protein, serum albumin, aspartate aminotransferase (AST/GOT) and alanine minotarnsferase (ALT/GPT). Kidney functions were also evaluated by the estimation of creatinine and urea levels. Serum total protein, ALT and AST activites were increased and albumin level were decreased in infected non - treated mice compared with non infected non treated group(control group). A decrease in T. Protein was also noticed as well as, ALT and AST levels in infected and treated mice by azithromycin as compared with infected non - treated mice and of proximate to non - infected treated mice with azithromycin ,albumin level showed increase in infected and treated mice by azithromycin compared with infected non - treated mice while the level of proximate to non infected and treated with azithromycin. It also revealed an increase in the level of urea of infected non treated mice compared to control group ,no significant differences between level of creatinine in all groups studied. It concluded that toxoplasmosis affects on liver and kidney functions by increasing the levels of T.protein, ALT,AST and urea activities then restore most parameters of infected treated mice into normal levels, owing to improvement of immune system of the infected treated mice. | ||
| Keywords | ||
| Biochemical Study; Toxoplasma Infection; Abino Mice | ||
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