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Spectrophotometric Determination of Rantidine-HCl in Pharmaceutical Formulations | ||
| Ibn Al-Haitham Journal For Pure And Applied Science | ||
| Article 1, Volume 23, Issue 2, 2010, Pages 89-97 | ||
| Author | ||
| A. S. Hammodi | ||
| Abstract | ||
| Spectrophotometric methods were developed for the determination of rantidine-HCl in pharmaceutical tablets. These methods were based on the reaction of DDQ and p-chloranil with rantidine-HCl, resulting in the formation of an orange-red and purple colored products which are quantified spectrophotometrically at 460 and 540nm in DDQ and p-chloranil, respectively. A graph of absorbance versus concentration show that Beer’s law is obeyed in a concentration ranges of 20-160 and (30-120)g/ml with molar absorptivities of 2.631 x 103 and 1.052 x 103l .mol-1-cm-1 for DDQ and p-chloranil, respectively.The optimum conditions for color development are described and the proposed methods were applied satisfactory to pharmaceutical preparations. | ||
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