Lipid Profile And Incidence Of Abetalipoproteinemia In Chronic Diarrhea Among Children Below Five Years Old

Hussein Alfaydawi, Ali

	Lipid Profile And Incidence Of Abetalipoproteinemia In Chronic Diarrhea Among Children Below Five Years Old
KUFA MEDICAL JOURNAL
Article 1, Volume 11, Issue 1, 2008, Pages 1-14
Author
Ali Hussein Alfaydawi
Abstract
Abstract: Objectives: This study was conducted to estimate the lipid profile in children below five years old with chronic dearrhia who were admitted in AL-ZAHRA’ hospital in Najaf in the period since 1st march to 31st July 2006 and to find out the insidence of ABETALIPOPROTEINEMIA (a rare aoutosomal resessive disease with potential lethal complications among them) for a better clinical approach to these patients. Method And Patients: 20 patients were investigated,male to female ratio was 3: 2, and by evaluating their history, comparing their growth parameters (weight,length, and head circumference) with a referral charts, then examination of their deep tendon reflexes, a sample of 5 ml. of venous blood was drown for detecting their lipid profile and searching for acanthocytosis in their blood films in addition to a stool sample send to the lab for general examination. Results: 80% of the patients were hypolipedemic (below normal values) but non of the patients fulfilled the criteria of Abetalipoproteinemia which include failure to thrive associated with acanthocytosis of the RBC, negative deep tendon reflexes with sever hypolipidemia (a total cholesterol level below 50 percent of their normal values, triglyceride below 20 mg./dl, absence of low density lipoprotein LDL,and undetectable levels of the very low density lipoprotein,VLDL). Conclution: Chronic dearrhia could be associated with hypolipidemia as a negative acute phace reactant to the stress of acute illness while the incidence of Abetalipoproteinemia among collected patients was zero percent.

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