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Protective effects of vitamin C on albino rats Exposed to hexavalent chromium (Cr vi) | ||
| KUFA MEDICAL JOURNAL | ||
| Article 1, Volume 11, Issue 1, 2008, Pages 84-88 | ||
| Authors | ||
| ; ; Heider Hemeed Abbas Al-Heidery | ||
| Abstract | ||
| Hexavalent chromium compounds are widely recognized as carcinogenic agent. Chromium intoxication is probably one of the most common forms of metals intoxication. Vitamin C has been reported as one of the more potent reductant of CrVi. The Exposure of rats to CrVI as (potassium dichromate) for 2 months day by day (25ppm (CrvI) in dinking water), induced an alterations in some biochemical parameters. Vit. C administration (150mg/l) in drinking water in combination with CrVi had prevented most of alterations induced by CrVi. Elevation of aspartate aminotransferase (SAT), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) activities in the blood and liver tissue, were recorded in the rats exposed to CrVi. Although most of these activities decreased near to control due to used Vit C. It's suggested that Vit.C. Administration could prevent toxic effects of Cr.VI probably by its anti-oxidant properties. | ||
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