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The Effect Of Hashish And Chlorpromazine On The Brain Dopamine Level | ||
| KUFA MEDICAL JOURNAL | ||
| Article 1, Volume 11, Issue 1, 2008, Pages 149-156 | ||
| Author | ||
| Jabbar Y. Al-Mayah | ||
| Abstract | ||
| The mesotelencephalic dopamine system has been shown to play an important role in rewarding effect of drug. The aim of the study is to determine the brain dopamine level in rats after hashish administration, and the effects of chlorpromazine on that level. Seventy-five male rats were enrolled in this experiment. The animals were randomly separated in to 3 groups, twenty-five rats in each group. Group 1 (self control group) was administered olive oil, 50 mg/kg I.P. bd, for seven days. Group 2 (hashish group) received hashish (50 mg/kg)[3] I.P. bd, for seven days. Group 3 received chlorpromazine, 5 mg/kg[4] was given I.P. 30 min earlier to hashish (50 mg/kg) I.P. bd, for seven days. The brain dopamine was determined by the tryhdroxyindole method of Chang. The brain dopamine level significantly increased after hashish administration and significantly decreased after hashish withdrawal, which might be responsible for hashish withdrawal symptoms. Chlorpromazine had no effect on the increases of the brain dopamine level which caused by hashish in the first few doses, but brain dopamine level significantly increased later on. | ||
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