Effects Of Selected Hormones And Obesity On Collagen Metabolism

M.Sc,; J. Majeed, Maysaa

	Effects Of Selected Hormones And Obesity On Collagen Metabolism
KUFA MEDICAL JOURNAL
Article 1, Volume 11, Issue 1, 2008, Pages 323-327
Authors
; Maysaa J. Majeed
Abstract
Back ground: The majority of obese persons have hyperinsulinemia and disturbances in the secretion of melatonin, catecholamine and pituitary, thyroid, adrenal and gonadal hormones. These hormones play an important role in the regulation of collagen metabolism either by acting directly or by influencing insulin like –growth factor (IGF-1) production. Aim: The objective of this paper was to assess whether and to what degree, the changes in serum level of insulin, insulin like growth factor -1 (IGF-1) and obesity may influence collagen metabolism. Patients and methods: A total of 100 subject were studied, 50 subject were obese and their mean of body mass index was (BMI) 33±9.2 and 50 subject were non-obese with their mean of BMI 22.5±2.1, all subject were apparently healthy. Collagen metabolism was evaluated indirectly from the measurement of selected markers of collagen biosynthesis procollagen type one (PCIP). Which was estimated in the serum using radioimmunoassay (RIA) method, by the same method each of IGF-1 and insulin was determined in the serum. Results: Obese subject had a significantly higher values for PCIP when compared with non -obese subject (160.2 ± 75.3 vs. 135.3 ± 27.4 p < 0.05), as well as obese subject showed significant increase in the concentration of insulin and IGF-1(40.8 ± 10.8 vs. 7.2 ± 3.3),(80.5 ± 15.0 vs. 35.5 ±8.5). The proportion of obese subject with high PCIP value of 250 ng/ml correspond to 90th percentile was 40% of obese subject, IGF-1 abnormalities was seen in 15% of obese subject and those non-obese subject had 20% abnormal value according to same percentile 90th. Conclusion: It can be concluded from the present study that increased collagen metabolism related to obesity in general and to hormonal (IGF-1 and insulin) disturbances in particular.

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