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Effect of Two Combined Oral Contraceptives On Selected | ||
| KUFA MEDICAL JOURNAL | ||
| Article 1, Volume 11, Issue 1, 2008, Pages 482-493 | ||
| Authors | ||
| Kufa College of Medicine; Najah R.Hadi Al-Mousawi | ||
| Abstract | ||
| The present study was undertaken to assess the effect of two combined oral contraceptives: Microgynon (ethinyl estradiol (EE2) 0.004906mg/kg and levonorgestrel (LNG) 0.024533mg/kg) and Nordiol (EE2 0.008177mg/kg and LNG 0.040889mg/kg) on selected oxidative stress parameters: reduced glutathione (GSH), lipid peroxidation byproduct malondialdehyde (MDA), catalase activity (CAT) and glutathione S-transferase enzyme activity (GST) and their effect on serum lipid profile(total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein (LDL) and very low density lipoprotein (VLDL) in female rats which were maintained on high cholesterol diet. Thirty female Sprague–Dawely rats were enrolled in this study, 6 rats were maintained on normal standard chow diet and considered as control group, the other 24 rats received high cholesterol diet for 14 weeks, then blood samples were taken randomly from 6 rats which underwent laparotomy, and experimental parameters were measured. The remaining 18 rats were randomly separated into 3 groups, six rats in each group; one group continued on high cholesterol diet and distilled water for 6 weeks and served as self control group. The other 2 groups continued on high cholesterol diet and one of the oral contraceptives mentioned above for 6 weeks. Then, the selected parameters were measured at the end of the 6 weeks of treatment. Results: Microgynon treatment decreased serum GSH significantly while did not significantly affect MDA level, CAT and GST activity. Microgynon treatment decreased serum high density lipoprotein (HDL) level significantly, while did not significantly affect serum TC, TG, LDL and VLDL. Nordiol treatment did not significantly affect serum level of GSH, MDA, CAT and GST. In Nordiol treatment serum TG and VLDL levels increased significantly, serum HDL level decreased significantly, other parameters of lipid profile did not significantly change. | ||
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