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Pathological study of colonic cancer by application of human epidermal growth factor receptor type II (Her-2 neu) | ||
| KUFA MEDICAL JOURNAL | ||
| Article 1, Volume 14, Issue 2, 2011, Pages 113-120 | ||
| Authors | ||
| ; ; Liwaa H. Al-Kelabi | ||
| Abstract | ||
| Abstract Background: This study aimed to assess the significance of human epidermal growth factor (HER-2/neu) protein overexpression and its possible correlation with clinicopathological parameters of patients with colonic cancer. Methods: FFPE (Formalin fixed, paraffin-embedded blocks) from 40 patients with colorectal carcinoma were included in this study. A group of 10 patients with benign lesions (polyp) were included as a comparative group and 10 normal colonic tissue sections were included as control group. Formalin fixed, paraffin-embedded blocks from 40 patients with colorectal cancer were included in this study. HER-2/ neu immunohistochemistry was performed using the HercepTest Kit (Dako, Glostrup, Denmark) according to the manufacturer's recommendations. Results: A total of 40 malignant cases were included.HER2/neu was considered as positive in(26 cases) 65% of colorectal carcinoma and a total of 10 benign colorectal lesions it was considered as positive in (7 cases)70% of it. So there is no significant difference from that of malignant cases (P>0.05). We did not find any significant difference between overexpression of HER-2/neu in relation to age and tumor stage (P>0.05), but there was significant difference in relation to tumor stage (P<0.05). Conclusion: Based upon the findings of this study, it can be concluded that HER-2/neu overexpression was observed in both colorectal cancer and benign colorectal lesions(polyps),no significant association with age, gender, tumor stage with significant difference in relation to tumor differentiation ,that mean HER-2/neu overexpression play an important role in the pathogenesis of colorectal cancer , which improve that the blocking of HER-2/neu may be a target for blocking the evolution and progression and hence improving the efficacy of anti-cancer therapy against this cancer. | ||
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