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The Effect of Olmesartan on Inflammation and Oxidative Stress in Animal Model of Hypertension | ||
| KUFA MEDICAL JOURNAL | ||
| Article 1, Volume 14, Issue 2, 2011, Pages 157-164 | ||
| Authors | ||
| University of Kufa; Ass. Prof. Dr. Abdul-Hussein A. Farage; ; Department of Biochemistry; ; ; Collage of Medicine | ||
| Abstract | ||
| Hypertension is one of the most common cardiovascular disease ; it is now widely accepted as a chronic inflammatory process. Low-grade inflammation, enhanced oxidant stress and lipid peroxidation play important roles in hypertension. Olmesartan exert a potent anti inflammatory activity by inhibition of inflammatory cytokines also it have anti oxidant effects.. The objective of present study was to assess the effect of olmesartan on hypertension via interfering with inflammatory and oxidative pathways Twenty Four white laboratory female Wistar rats were assigned to three groups (Eight rats ) in each group. Two groups of these three groups were induced with hypertension by giving intraperetonial injections of synthetic ACTH (0.5mg/kg/day) for Fifteen days. One of these tow induced groups were Olmesartan treated group: The other one was control untreated. Blood samples were collected at the end of induction of hypertension (2ed week) and after 8 weeks of treatment for measurement of serum (hsCRP, IL6, TNF-α ,malondialdehyde (MDA), and reduced glutathione (GSH) At the end of the eight weeks the hearts were removed for assessment the histopathological changes. Compared with the control normal group, levels of hscRP, IL6, TNF-α ,MDA, and Blood pressure were increased and reduced GSH was decreased in hypertensive animals (P<0.05). Histologically, all induced- untreated rats showed no significant changing (P>0.05). Olmesartan decreased the levels in hsCRP, IL6, TNF-α, MDA significantly compared with hypertensive untreated group (P<0.05), It also caused significant decrease in blood pressure and significant increase in GSH (P<0.05), it didn’t show significant histological changing compared with induced untreated group p>0.05. Olmesartan possess antihypertensive effects in experimentally induced hypertensive rats via interfering with inflammatory and oxidative pathways. | ||
| Keywords | ||
| Olmesartan; inflammatory markers; oxidative stress | ||
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