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Spectrophotometric Determination of Diphenhydramine hydrochloride and Application to Pharmaceutical Preparations | ||
| Tikret Journal of Pharmaceutical Sciences | ||
| Article 1, Volume 8, Issue 1, 2012, Pages 139-146 | ||
| Author | ||
| Qabas Naji Rashid | ||
| Abstract | ||
| The research involves the use of analytical method for determination of the diphenhydramine hydrochloride (DPH) drug in some pharmaceutical preparations using molecular absorption technique (UV-Vis.) in addition to the investigating of complexes obtained. The optimum analytical data obtained throughout of study could be summarized as follows: order of addition (DPH + 2% CS2 in CHCl3+Ag(I), pH(11),volume of ammonia solution (1ml), concentration of Ag(I) (8µg/ml), aqueous : organic phase ratio 1:1, reaction time (4 minutes), extraction time (8minutes), reaction temperature 25oC, one extraction process, extraction ratio (E%=99.82) chloroform proved to be the best solvent for extraction of DPH-Ag complex without interferences, λmax.=363nm. The analytical figures obtained were: linear dynamic range (0.25-80µg/ml)for DPH , RSD% (0.396), D.L (0.29µg/ml), Erel% (0.125), recovery (99.87%).This method was applied for determination of DPH in pharmaceutical preparation (syrup) using direct and standard addition methods, recovery's was found to be (97.8%, 98.2 %). | ||
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