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Preliminary screening of bioactive metabolites from three fungal species of Drechslera isolated from soil in Basrah, Iraq | ||
| Journal of Basrah Researches (Sciences) | ||
| Article 1, Volume 38, Issue 2, 2012, Pages 44-53 PDF (0 K) | ||
| Authors | ||
| Halla M. Mohammad; ; Tawfik M. Muhsin | ||
| Abstract | ||
| Screening of secondary metabolites from three fungal species of the genus Drechslera was made. Fungal extraction was carried out by ethyl acetate solvent. Bioactivity of fungal extracts against E. coli and S. aureus by using a disc diffusion technique was examined. All fungal extracts exhibited an inhibitory action against both bacterial isolates.The inhibition zones exhibited by fungal extracts ranged between 22-28 mm diam. MIC test revealed that the extract of D. australiensis exhibited a minimal inhibition values (12.5 and 6.25 ug/L) against E. coli and S. aureus, respectively. The bioactivities of extracts after being stored for six months at 8 ◦C were slightly decreased as compared with initial freshly prepared extracts. A comparison between the inhibitory action of five commercial drugs and the fungal extracts showed that the extracts rendered a greater bioactivity than the examined drugs, with an exception of chloramphenicol. Chemical analysis showed that extract of D. ausraliensis contains Tannin compounds while D. halodes and D. hawaiinsis contain alkaloids | ||
| Keywords | ||
| Antibiotics; alkaloids; bacteria; bioactive metabolites; drugs; Fungi; growth inhibition zones; tannin | ||
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