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A method for production of a novel nucleosidal antibiotic SH1 from streptomyces rimosus isolated locally | ||
| basrah journal of science | ||
| Article 1, Volume 24, Issue 1, 2006, Pages 1-20 PDF (0 K) | ||
| Authors | ||
| ; ; ; M. S; ; | ||
| Abstract | ||
| SH1 antibiotic active against gram positive and gram negative bacteria was isolated from strain resembling Streptomyces rimosus isolated from soil of southern Iraq. The antibiotic was isolated as hygroscopic brown powder with maximum yield 3 gm/L at (28-30)oC. physiochemical properties (thin layer chromatograph (TLC) ; IR. Spectrum; UV-spectrum; CHN percent, melting point, solubility in organic and inorganic solvents and coloumetric testes) of extracted antibiotic was determined. It’s minimal inhibitory concentration (MIC) was determined against bacterial isolates which varied between (1-250) mg/ml. The a cute toxicity (LD50) in laboratory animals was of 250 mg/kg. The toxicity of extracted antibiotic (SH1) against human red blood cells and it’s stability in different range of pH and temperature were studied. The effect of extracted antibiotic (SH1) on reference strain Staphylococcus aureus NCTC 6571 DNA was studied and the concentration 0.75 mg/ml of (SH1) appeared the high turbidity in DNA solution of S. aureus NCTC 6571. | ||
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