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Synthesis and characterization of the compound 2,2-diamino-2,5-di(4-hydroxyphenyl)-4-oxo-5-thioryl-(1,2,4) Oxadizolidine (Oxa.) that had a biological activity | ||
| basrah journal of science | ||
| Article 1, Volume 24, Issue 1, 2006, Pages 88-103 PDF (0 K) | ||
| Authors | ||
| Awatif H.I Al-Mohasin; Shurooq S. G. Al; Israa A. H. Al- Hawani; Balsam A. Marina; Mosa wi | ||
| Abstract | ||
| The compound 2,2-diamino-2.5-di(4-hydroxyphenyl)-4-oxo-5-thioureayl-(1,2,4) oxadizolidene (Oxa.) was prepared by 1,3 dipolar cycloaddition reaction between α-(4-hydroxy phenyl)-N-benzyland thiourea alken. The compound Oxa. was purified by colum chromatography techniques. It’s purity tested by using thin layer chromatography technique and showed single spot. The compound Oxa. was characterized by using spectroscopic techniques like IR , UV , Ms spectrum The in correct melting point for Oxa. was 295-297 oC. The spectrum of biological activity of Oxa. Was broad , it was effective against reference strains of gram negative Escherichia coli ATCC 25922، Pseudomonas aeruginosa ATCC 27853 and gram positive Staphylococcus aureus ATCC 25923 by used 100 μg disk of Oxa. . The median lethal dose LD50 was (11.7 g/kg) this made it within the class of slightly toxic substances , it Could be use in treatment by a dose 0.117 g/kg . | ||
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