Abdul Sattar Alubydi, M., B. Dikran, S., K. Mohammed, A. (2011). Univariate and Simplex Optimization for The Analysis of Diphenhydramine-HCl Through Ion-pair Formation. , 24(1), 163-174.
M. Abdul Sattar Alubydi; S. B. Dikran; A. K. Mohammed. "Univariate and Simplex Optimization for The Analysis of Diphenhydramine-HCl Through Ion-pair Formation". , 24, 1, 2011, 163-174.
Abdul Sattar Alubydi, M., B. Dikran, S., K. Mohammed, A. (2011). 'Univariate and Simplex Optimization for The Analysis of Diphenhydramine-HCl Through Ion-pair Formation', , 24(1), pp. 163-174.
Abdul Sattar Alubydi, M., B. Dikran, S., K. Mohammed, A. Univariate and Simplex Optimization for The Analysis of Diphenhydramine-HCl Through Ion-pair Formation. , 2011; 24(1): 163-174.

Univariate and Simplex Optimization for The Analysis of Diphenhydramine-HCl Through Ion-pair Formation

Ibn Al-Haitham Journal For Pure And Applied Science
Article 1, Volume 24, Issue 1, 2011, Pages 163-174
Authors
M. Abdul Sattar Alubydi; S. B. Dikran; A. K. Mohammed
Abstract
A Simple, rapid and sensitive extractive and spectrophotometric method has been described for the analysis of diphenhyldramine –HCl (DPH) in pure form and in pharmaceutical formulations. The method is based on the formation of chloroform soluble ion-pair complex with Bromophenol blue(BPB) in a phthalate buffer at pH 3.0.The extracted complex shows maximum absorbance at 410 nm. Beer's law is obeyed in the concentration range 0.2-25.0 µg.ml-1. The molar absorptivity and Sandell's sensitivity for the system being 2.416x104 L.mol-1.cm-1 and 0.012µg.cm-2, respectively. The limit of detection was found to be 0.155 µg.ml-1.The proposed method was successfully applied to the determination of the drug in pharmaceutical formulation and satisfactory results were obtained.
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