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Preparation and study of controlled release , Biological activity of polymer griseofulvin delivery matrix against some fungal isolates | ||
| basrah journal of science | ||
| Article 1, Volume 25, Issue 1, 2007, Pages 28-43 PDF (0 K) | ||
| Author | ||
| Inaam M. N. Alrubayae | ||
| Abstract | ||
| In this study the activity of poly (vinyl alcohol) hydrogel was loaded with antifungal griseofulvin against three types of fungal isolates including Candida albicans, Cryptococcus neoformans, and Fusarium oxysporum in comparison with activity of griseofulvin alone in different periods. Polymer griseofulvin delivery was more effective with high significant difference than griseofulvin alone. While the activity of polymer alone was studied against same isolates we showed that it has no activity against all isolates. The release rate of griseofulvin from polymeric matrix was studied by using spectrophotometric U.V. technique at constant temperature 37oC and wave length 293 and 290 nm of each simulated gastric fluid (SGF) and in simulated intestinal fluid (SIF). In addition to the swelling ratio of the polymer griseofulvin delivery system was determined | ||
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